Cardiovascular Research

Peer-Reviewed Cardiorenal Models for Pharmaceutical R&D

Our models are built on a strong scientific foundation and reflect over 16 years of focused development in kidney and cardiovascular systems modeling.

Developed, peer-reviewed, and published by the Cardiorenal Systems Physiology Lab at the University of Georgia College of Engineering, these models offer unmatched depth and rigor. While many companies use them, we bring unique, first-hand expertise in their development. Our models have been extensively validated through peer-review and published in leading scientific journals. We are now developing tools and resources to make these published models more accessible and user-friendly (coming soon).

Kidney Model

Kidney and Fluid Homeostasis Multi-scale Model

Our core, peer-reviewed model provides a comprehensive framework for understanding kidney function and its systemic effects.

This model has been extensively published and peer-reviewed in leading scientific journals. Key Publications

Kidney and Fluid Homeostasis Model Schematic
Key Biomarkers and Variables: SBP/DBP, GFR, Urine and Plasma Sodium, Urine Volume, Blood Volume, Interstitial Fluid Volume, Renin, Aldosterone, Atrial Natriuretic Peptide (ANP), Vasopressin, Endothelin-1
Virtual Populations: Healthy, Essential Hypertensives, Resistant Hypertensives, Hyperaldosteronism

Model Extensions

Chronic Kidney Disease Model

Chronic Kidney Disease Model

Simulates CKD progression by simulating kidney injury processes (glomerulosclerosis, tubular atrophy and fibrosis, interstitial fibrosis, podocyte injury, etc.), nephron loss, proteinuria and GFR decline over time.

This model has been extensively published and peer-reviewed in leading scientific journals. Key Publications

Chronic Kidney Disease Model Graphs
Key Biomarkers and Endpoints: eGFR, UACR, eGFR Slope, Serum Creatinine, Renal Events including End Stage Renal Disease (ESRD) and Doubling of Serum Creatinine
Virtual Populations: Diabetic Kidney Disease (DKD), Hypertensive Kidney Disease, Focal Segmental Glomerulosclerosis (FSGS), IgA Nephropathy
Cardiac-Kidney Model

Cardiac-Kidney Model

Integrates cardiac function with kidney physiology to simulate heart failure and cardiorenal syndromes.

This model has been extensively published and peer-reviewed in leading scientific journals. Key Publications

Cardiac-Kidney Model Diagram
Key Biomarkers and Endpoints: Cardiac Output, Ejection Fraction, Left Ventricular End-Diastolic Pressure (LVEDP), Pulmonary Capillary Wedge Pressure (PCWP), NT-proBNP
Virtual Populations: Heart Failure with Reduced Ejection Fraction (HFrEF), Heart Failure with Preserved Ejection Fraction (HFpEF), Cardiorenal Syndrome
Other Model Extensions

Other Extensions

Additional specialized modeling capabilities that extend our core platform:

1) Potassium-Aldosterone-Sodium Homeostasis Model

Allows simulation of standard-of-care and novel therapeutics effects on serum potassium and hyperkalemia.

2) Proximal Tubule Bioenergetics

Models energy metabolism and transport processes in proximal tubule cells.

3) Drug-Induced Kidney Injury

Simulates mechanisms and progression of nephrotoxicity and relevant biomarkers including serum creatinine, Kim-1, and alpha-GST.

4) Biophysics of Glomerular Flow

Models fluid dynamics and filtration mechanics at the glomerular level.

Our Core Capabilities

Mechanistic Modeling

Deep physiological understanding through mathematical modeling of kidney-cardiovascular interactions

Simulation & Analysis

Predictive simulations to understand drug effects and optimize development strategies

Strategic Insights

Data-driven recommendations to guide critical development decisions