Cardiorenal QSP

Modeling integrated kidney–cardiovascular function to drive confident, science-based decisions

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Complex Decisions Require Mechanistic Insight

When your novel therapy shows promising efficacy but unforeseen changes in kidney biomarkers, how can you confidently determine the next development step?

When combining therapies with overlapping renal effects, can you predict the benefits and risks across patient populations?

When your Phase 2 data shows promising cardiovascular responses but unexpected serum electrolyte changes, how do you design Phase 3 to capture the full story?

These are some of the critical decision points where mechanistic insight makes the difference between confident advancement and costly uncertainty. Cardiorenal Quantitative Systems Pharmacology (QSP) models illuminate complex interactions by connecting molecular mechanisms to physiological responses to clinical outcomes.

Through this approach, Cardiorenal QSP helps you:

Decode unexpected findings – When biomarkers move in counterintuitive directions, understand the underlying physiology driving those changes
Optimize combination strategies – Predict how multiple therapies will interact across interconnected cardiorenal pathways

Design informative trials – Identify optimal endpoints, timepoints, and patient populations to capture your drug's true risk-benefit profile
Strengthen regulatory discussions – Present data within a mechanistic framework that demonstrates comprehensive understanding of your therapy's effects

Expertise

At Cardiorenal QSP, we combine deep domain knowledge of cardiorenal physiology, disease, and pharmacology with 16+ years of technical and practical expertise in applying mechanistic models to support pharmaceutical R&D.

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Technology

Our peer-reviewed mechanistic computational models integrate molecular mechanisms with physiological responses to predict drug effects across interconnected organ systems.

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Services

Choose from flexible engagement models ranging from targeted project work to ongoing strategic partnerships, with clearly defined deliverables tailored to your program requirements.

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About

Dr. K. Melissa Hallow, Ph.D., combines rigorous academic research in cardiorenal physiology with extensive pharmaceutical industry experience. Her scientific approach to drug development challenges is grounded in both rigorous research and practical problem-solving.

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Contact

K. Melissa Hallow Ph.D.
Athens, GA USA

hallowkm@cardiorenalqsp.com